Regulation of heart rate by chemical signal

Across TCGA patient cohorts, RNA activity of the Regulation of heart rate by chemical signal pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPC6, RPAP3, and SERPINF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart rate by chemical signal activity versus GPC6 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GPC6 →	+0.537	+0.082	<.001	<.001	3	6
LSCC	RPAP3 →	-0.200	-0.060	<.001	.001	3	5
COAD	SERPINF1 →	+0.816	+0.038	<.001	.001	3	5
BRCA	TLN1_S1201 →	+0.777	+0.083	.001	<.001	3	5
UCEC	VCL_S272 →	+0.572	+0.079	<.001	.004	2	6
COAD	NID2 →	+0.501	+0.051	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003062 vs GPC6 — BRCA

Explore this scatter interactively →