Regulation of heart rate by chemical signal

Across TCGA patient cohorts, RNA activity of the Regulation of heart rate by chemical signal pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFR3A, CCNP, and ATP1B3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart rate by chemical signal activity versus EFR3A in LUAD (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EFR3A →	-0.297	-0.604	.004	<.001	3	3
BRCA	CCNP →	+1.237	+0.434	.001	.002	3	3
BRCA	ATP1B3 →	-0.395	-0.360	.005	.007	3	3
GBM	STT3A →	-0.159	-0.490	.008	.001	3	3
GBM	CCT5 →	-0.252	-0.487	<.001	.001	3	3
PDAC	ARPC2 →	-0.270	-0.086	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003062 vs EFR3A — LUAD

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