Regulation of vascular associated smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Regulation of vascular associated smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are R3HCC1, PSME2P6, and SUMO2P21, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vascular associated smooth muscle contraction activity versus R3HCC1 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	R3HCC1 →	+0.310	+0.430	.009	.001	3	3
BRCA	PSME2P6 →	+0.768	+0.699	<.001	<.001	3	3
BRCA	SUMO2P21 →	+0.796	+0.541	.004	.005	3	3
LUAD	LMLN →	-0.328	-0.421	<.001	.004	3	3
LSCC	ZNF213-AS1 →	-0.304	-0.714	.008	.003	3	3
LSCC	KIFAP3 →	-0.373	-0.672	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003056 vs R3HCC1 — BRCA

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