Regulation of vascular associated smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Regulation of vascular associated smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF276, ZNF587B, and TM9SF4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF276 grouped by Regulation of vascular associated smooth muscle contraction-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZNF276 →	-1.063	-1.550	.001	.002	3	4
BLOOD_Leukemia	ZNF587B →	+0.508	+1.105	.008	.004	3	4
OVARY	TM9SF4 →	-0.515	-0.967	.005	.008	3	3
OESOPHAGUS	SELENBP1 →	-2.453	-1.209	.001	.004	3	3
OESOPHAGUS	MAMDC2 →	-1.812	-1.216	.001	<.001	3	3
BLOOD_Lymphoma	CTSH →	+4.287	+1.277	.008	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF276 by Regulation of vascular associated smooth muscle contraction activity — BLOOD_Myeloma

Explore this box plot interactively →