Regulation of vascular associated smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Regulation of vascular associated smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICOS13, MPG, and GPR137C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vascular associated smooth muscle contraction activity versus MICOS13 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MICOS13 →	+0.711	+1.468	.004	.002	3	4
OVARY	MPG →	+1.097	+1.462	<.001	<.001	3	4
OVARY	GPR137C →	-1.302	-1.383	<.001	<.001	3	4
LUNG_NSCLC_LUAD	KANSL1L →	-0.478	-0.749	.009	.001	3	4
PANCREAS	PLBD2 →	+0.701	+1.260	<.001	<.001	3	4
PANCREAS	GPX4 →	+0.641	+1.173	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003056 vs MICOS13 — UPPER_AERODIGESTIVE_TRACT

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