Regulation of systemic arterial blood pressure mediated by a chemical signal

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure mediated by a chemical signal pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ESF1, MPHOSPH10, and AATF, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure mediated by a chemical signal activity versus ESF1 in OV (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ESF1 →	-0.456	-0.046	<.001	<.001	3	9
LSCC	MPHOSPH10 →	-0.328	-0.037	<.001	<.001	3	9
GBM	AATF →	-0.365	-0.100	<.001	<.001	3	8
PDAC	SYNM →	+0.745	+0.034	.003	.001	3	8
UCEC	TPM1 →	+0.517	+0.043	<.001	.001	3	8
LSCC	UBR5 →	-0.268	-0.041	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003044 vs ESF1 — OV

Explore this scatter interactively →