Regulation of systemic arterial blood pressure mediated by a chemical signal

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure mediated by a chemical signal pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFPT2, ROBO4, and ARHGEF15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure mediated by a chemical signal activity versus GFPT2 in UCEC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GFPT2 →	+0.727	+0.495	.003	.003	3	6
LUAD	ROBO4 →	+0.417	+0.146	.006	.006	3	6
BRCA	ARHGEF15 →	+0.627	+0.178	<.001	<.001	3	6
HNSC	LILRA1 →	+0.407	+0.115	.002	.005	3	5
HNSC	CADM3 →	+0.799	+0.163	<.001	.001	3	5
BRCA	VSTM4 →	+0.847	+0.173	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003044 vs GFPT2 — UCEC

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