Regulation of systemic arterial blood pressure mediated by a chemical signal

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure mediated by a chemical signal pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CREB5, HPS3, and TSPAN4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CREB5 grouped by Regulation of systemic arterial blood pressure mediated by a chemical signal-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CREB5 →	-1.693	-1.204	.003	.002	3	6
LUNG_NSCLC_LUSC	HPS3 →	-1.520	-1.285	.003	.002	3	4
LIVER	TSPAN4 →	-1.000	-1.497	.003	<.001	3	4
BREAST	HSD11B2 →	+1.292	+0.629	.004	.008	3	4
URINARY_TRACT	DPYSL2 →	-2.564	-1.634	.005	<.001	3	4
LARGE_INTESTINE	ZBTB18 →	-1.385	-0.705	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CREB5 by Regulation of systemic arterial blood pressure mediated by a chemical signal activity — URINARY_TRACT

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