Regulation of systemic arterial blood pressure mediated by a chemical signal

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure mediated by a chemical signal pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL3, STARD13, and MMP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure mediated by a chemical signal activity versus RPL3 in CNS (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RPL3 →	-0.636	-0.284	.008	.004	3	5
LIVER	STARD13 →	+1.562	+0.392	.001	.002	3	5
BREAST	MMP2 →	+3.566	+0.249	.001	.009	3	5
STOMACH	CPQ →	+1.895	+0.329	.002	.001	3	5
SOFT_TISSUE	TNFRSF12A →	+1.487	+0.277	<.001	.003	3	5
LUNG_NSCLC_LUSC	SNTA1 →	+1.644	+0.314	.006	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003044 vs RPL3 — CNS

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