Regulation of systemic arterial blood pressure by baroreceptor feedback

pathway activity — cross-omics
GO:0003025Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure by baroreceptor feedback pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANK2, SPAG1_S418, and TNS2_S648, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADANK2 →-0.339-0.166<.001<.00136
UCECSPAG1_S418 →+0.867+0.180.003.00135
LUADTNS2_S648 →-0.644-0.276<.001<.00135
HNSCPALM →-0.709-0.368<.001.00135
LUADPLCL2_S1113 →-0.616-0.207<.001<.00135
LUADVWF →-0.313-0.188<.001.00535
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration