Vascular process in circulatory system

Across TCGA cell cohorts, RNA activity of the Vascular process in circulatory system pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSTF1, SCGB2B2, and KLHL15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular process in circulatory system activity versus OSTF1 in STOMACH (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OSTF1 →	+1.534	+0.237	.002	.007	2	7
UPPER_AERODIGESTIVE_TRACT	SCGB2B2 →	-0.232	-0.177	.006	<.001	3	6
SKIN	KLHL15 →	-0.528	-0.125	.007	.008	3	5
URINARY_TRACT	F3 →	+4.717	+0.286	.002	.009	3	4
URINARY_TRACT	GPSM3 →	+1.778	+0.234	.005	.005	3	4
STOMACH	ZNF775 →	-1.174	-0.162	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003018 vs OSTF1 — STOMACH

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