Heart process

Across TCGA cell cohorts, RNA activity of the Heart process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBED6CL, RPL18A, and C1orf74, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBED6CL grouped by Heart process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZBED6CL →	-1.469	-0.219	<.001	<.001	3	4
PANCREAS	RPL18A →	-0.917	-0.206	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	C1orf74 →	-1.626	-0.182	.003	.003	3	3
UPPER_AERODIGESTIVE_TRACT	C8orf33 →	+1.139	+0.233	<.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	ADH5 →	+1.581	+0.239	.003	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ASB1 →	+1.234	+0.207	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBED6CL by Heart process activity — BREAST

Explore this box plot interactively →