Heart process

Across TCGA cell cohorts, RNA activity of the Heart process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR15, APOBR, and VAMP8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart process activity versus PRR15 in PANCREAS (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRR15 →	+3.059	+0.379	.001	.004	3	6
LUNG_SCLC	APOBR →	+0.076	+0.229	.001	<.001	3	6
BREAST	VAMP8 →	+2.785	+0.230	.003	.004	2	6
BLOOD_Leukemia	NCF4 →	+2.747	+0.165	<.001	.003	3	5
BLOOD_Leukemia	C12orf73 →	-0.441	-0.181	.005	.001	3	5
PANCREAS	INSIG2 →	+1.254	+0.237	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003015 vs PRR15 — PANCREAS

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