Renal system process

Across TCGA cell cohorts, RNA activity of the Renal system process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAP1, APMAP, and DDX52, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAP1 grouped by Renal system process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRAP1 →	+0.544	+0.550	.002	.009	3	4
PANCREAS	APMAP →	+1.007	+0.801	<.001	.009	3	3
PANCREAS	DDX52 →	-0.681	-0.589	.001	.004	3	3
SKIN	TIMM44 →	+0.447	+0.836	.002	<.001	3	3
SKIN	PLA2G4C →	-0.830	-0.890	.007	<.001	2	4
SKIN	RRAS →	-1.668	-1.015	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAP1 by Renal system process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →