Renal system process

Across TCGA cell cohorts, RNA activity of the Renal system process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IKBIP, MELTF, and UBE2A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal system process activity versus IKBIP in OVARY (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IKBIP →	+1.165	+0.275	.008	.004	2	7
STOMACH	MELTF →	+2.552	+0.247	<.001	.003	3	5
LIVER	UBE2A →	+1.110	+0.325	.001	.007	2	6
OESOPHAGUS	GNAI2 →	+1.328	+0.543	.004	<.001	3	5
OVARY	GNG12 →	+1.584	+0.270	.003	.002	3	5
OVARY	FMN1 →	+1.420	+0.227	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003014 vs IKBIP — OVARY

Explore this scatter interactively →