Skeletal muscle contraction

Across TCGA patient cohorts, RNA activity of the Skeletal muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP6, RGS18, and CALHM5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle contraction activity versus GIMAP6 in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GIMAP6 →	+1.002	+0.667	<.001	<.001	3	5
HNSC	RGS18 →	+0.620	+0.626	<.001	.003	3	5
COAD	CALHM5 →	+0.514	+0.762	.002	.001	3	5
LSCC	TMEM273 →	+0.808	+0.478	<.001	.001	3	5
HNSC	FLI1 →	+0.928	+0.856	<.001	<.001	3	5
HNSC	PTGIS →	+1.503	+0.695	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003009 vs GIMAP6 — HNSC

Explore this scatter interactively →