Skeletal muscle contraction

Across TCGA patient cohorts, RNA activity of the Skeletal muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASPA, RTN2, and GNG11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle contraction activity versus ASPA in HNSC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ASPA →	+0.894	+0.838	<.001	<.001	3	5
HNSC	RTN2 →	+1.278	+0.543	<.001	<.001	3	4
HNSC	GNG11 →	+0.743	+0.940	<.001	<.001	3	4
LSCC	SEPTIN4_S117 →	+1.045	+0.713	<.001	<.001	2	5
HNSC	ANK2 →	+0.949	+0.881	<.001	<.001	3	4
HNSC	ANK2_S3793 →	+1.185	+0.820	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003009 vs ASPA — HNSC

Explore this scatter interactively →