Skeletal muscle contraction

Across TCGA cell cohorts, RNA activity of the Skeletal muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD72, DEPP1, and NUS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle contraction activity versus CD72 in BREAST (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CD72 →	+0.438	+0.149	.004	.005	3	5
SKIN	DEPP1 →	+1.820	+0.155	.002	.005	3	4
KIDNEY	NUS1 →	-1.507	-0.342	.008	.004	3	4
KIDNEY	C5orf34 →	-1.000	-0.309	.003	.004	3	4
KIDNEY	NDE1 →	-1.303	-0.258	.003	.007	3	4
LARGE_INTESTINE	PLK4 →	-0.986	-0.166	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003009 vs CD72 — BREAST

Explore this scatter interactively →