tRNA threonylcarbamoyladenosine modification

Across TCGA patient cohorts, RNA activity of the tRNA threonylcarbamoyladenosine modification pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NIF3L1, OSGEPL1, and SSB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA threonylcarbamoyladenosine modification activity versus NIF3L1 in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NIF3L1 →	+0.311	+0.043	.006	.001	3	8
LSCC	OSGEPL1 →	+0.455	+0.052	<.001	<.001	3	8
LSCC	SSB →	+0.356	+0.079	<.001	<.001	3	7
LSCC	WRNIP1 →	+0.355	+0.060	<.001	<.001	3	6
LSCC	XRCC6 →	+0.230	+0.067	.002	<.001	3	6
CCRCC	SND1_S645 →	-0.819	-0.031	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002949 vs NIF3L1 — OV

Explore this scatter interactively →