tRNA threonylcarbamoyladenosine modification

Across TCGA patient cohorts, RNA activity of the tRNA threonylcarbamoyladenosine modification pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YRDC, C2orf66, and PSMB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA threonylcarbamoyladenosine modification activity versus YRDC in OV (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	YRDC →	+0.406	+0.138	<.001	<.001	3	5
HNSC	C2orf66 →	+0.441	+0.096	.009	.002	3	4
BRCA	PSMB2 →	+0.620	+0.151	<.001	<.001	3	4
BRCA	NEBL →	-0.811	-0.119	.006	.003	3	4
CCRCC	POF1B →	-1.312	-0.180	.007	<.001	3	4
HNSC	PPAT →	+0.507	+0.103	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002949 vs YRDC — OV

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