tRNA threonylcarbamoyladenosine modification

Across TCGA cell cohorts, RNA activity of the tRNA threonylcarbamoyladenosine modification pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMOD3, SH3TC1, and CCDC9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMOD3 grouped by tRNA threonylcarbamoyladenosine modification-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMOD3 →	+1.145	+0.379	.006	.006	3	4
BREAST	SH3TC1 →	+1.379	+0.195	.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	CCDC9 →	+0.800	+0.175	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	HMGCL →	+1.120	+0.203	.009	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SPSB3 →	+1.153	+0.203	.002	.001	3	3
UPPER_AERODIGESTIVE_TRACT	STX5 →	+0.710	+0.164	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMOD3 by tRNA threonylcarbamoyladenosine modification activity — STOMACH

Explore this box plot interactively →