tRNA threonylcarbamoyladenosine modification

Across TCGA cell cohorts, RNA activity of the tRNA threonylcarbamoyladenosine modification pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS21, CTAGE8, and PDE3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA threonylcarbamoyladenosine modification activity versus MRPS21 in SOFT_TISSUE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MRPS21 →	+0.716	+0.363	.001	.008	3	4
OVARY	CTAGE8 →	-1.376	-0.403	.009	.006	3	4
OVARY	PDE3B →	+1.785	+0.342	<.001	.003	3	4
LARGE_INTESTINE	PNPT1 →	+0.647	+0.214	.003	.005	3	4
OVARY	CAD →	+0.980	+0.349	.008	.007	3	4
OESOPHAGUS	UBE2J1 →	+1.268	+0.385	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002949 vs MRPS21 — SOFT_TISSUE

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