Desmosome organization

Across TCGA patient cohorts, RNA activity of the Desmosome organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DSG2, DSP_S22, and BAIAP2L1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Desmosome organization activity versus DSG2 in LSCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DSG2 →	+0.488	+0.067	<.001	<.001	3	6
CCRCC	DSP_S22 →	+0.969	+0.100	<.001	<.001	3	6
BRCA	BAIAP2L1 →	+0.449	+0.049	<.001	<.001	3	5
LSCC	DSC2 →	+0.662	+0.068	<.001	<.001	3	5
GBM	FOSL2_S200 →	+0.404	+0.073	<.001	.002	3	5
UCEC	IVL →	+2.106	+0.101	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002934 vs DSG2 — LSCC

Explore this scatter interactively →