Desmosome organization

Across TCGA patient cohorts, RNA activity of the Desmosome organization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PERP, CARD8-AS1, and DSP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Desmosome organization activity versus PERP in LSCC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PERP →	+1.094	+0.558	<.001	<.001	3	7
UCEC	CARD8-AS1 →	-0.538	-0.249	.002	.006	3	7
CCRCC	DSP →	+2.014	+1.061	<.001	<.001	3	7
HNSC	SLA2 →	-0.580	-0.456	.001	.009	3	6
COAD	IL10RA →	-0.637	-0.389	<.001	.007	3	6
COAD	TYROBP →	-0.991	-0.425	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002934 vs PERP — LSCC

Explore this scatter interactively →