Desmosome organization

Across TCGA cell cohorts, RNA activity of the Desmosome organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4H, ZNF433, and FAM228B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF4H grouped by Desmosome organization-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	EIF4H →	+0.711	+1.662	.001	<.001	3	3
BLOOD_Lymphoma	ZNF433 →	-1.617	-2.045	.007	<.001	3	3
BLOOD_Lymphoma	FAM228B →	-2.295	-2.133	<.001	<.001	3	3
STOMACH	MXD4 →	-1.497	-1.252	<.001	.001	3	3
STOMACH	DUSP5 →	-3.150	-1.174	.002	.003	3	3
STOMACH	LYST →	-1.130	-1.515	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF4H by Desmosome organization activity — BLOOD_Lymphoma

Explore this box plot interactively →