Desmosome organization

Across TCGA cell cohorts, RNA activity of the Desmosome organization pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR1L6, KRIT1, and MYBL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR1L6 grouped by Desmosome organization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR1L6 →	-0.308	-1.462	<.001	.001	2	5
LARGE_INTESTINE	KRIT1 →	-0.130	-0.268	.002	.001	3	4
LUNG_NSCLC_LUAD	MYBL2 →	+0.386	+0.201	.001	.002	3	4
OESOPHAGUS	PTF1A →	-0.096	-0.127	.009	<.001	3	4
LUNG_NSCLC_LUAD	CLTC →	+0.503	+0.218	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PCBP2 →	-0.192	-0.241	.006	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR1L6 by Desmosome organization activity — BLOOD_Leukemia

Explore this box plot interactively →