Desmosome organization

Across TCGA cell cohorts, RNA activity of the Desmosome organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH1, CBLC, and TC2N, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Desmosome organization activity versus CDH1 in URINARY_TRACT (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CDH1 →	+5.000	+0.789	<.001	<.001	3	11
STOMACH	CBLC →	+3.757	+0.874	<.001	<.001	3	11
STOMACH	TC2N →	+3.730	+0.790	<.001	<.001	3	10
LIVER	MYH14 →	+4.458	+1.433	<.001	.006	3	10
URINARY_TRACT	GRHL2 →	+3.823	+0.781	<.001	<.001	3	10
URINARY_TRACT	ANO9 →	+2.067	+0.833	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002934 vs CDH1 — URINARY_TRACT

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