Lipid hydroxylation

Across TCGA cell cohorts, RNA activity of the Lipid hydroxylation pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF19, DEGS2, and EXTL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRPF19 grouped by Lipid hydroxylation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRPF19 →	-0.259	-1.528	.006	<.001	3	4
LUNG_SCLC	DEGS2 →	+0.218	+1.157	.006	.007	3	4
STOMACH	EXTL2 →	+0.243	+1.488	.006	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NR2E1 →	+0.142	+1.575	.004	.001	3	3
UPPER_AERODIGESTIVE_TRACT	TRIM5 →	+0.199	+1.849	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ANKHD1-EIF4EBP3 →	+0.147	+1.175	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRPF19 by Lipid hydroxylation activity — OESOPHAGUS

Explore this box plot interactively →