Regulation of humoral immune response mediated by circulating immunoglobulin

Across TCGA patient cohorts, RNA activity of the Regulation of humoral immune response mediated by circulating immunoglobulin pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGER4, PPAT, and SLC11A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of humoral immune response mediated by circulating immunoglobulin activity versus PTGER4 in GBM (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTGER4 →	+0.773	+0.248	<.001	<.001	3	5
GBM	PPAT →	-0.364	-0.170	.002	.007	3	5
OV	SLC11A1 →	+0.612	+0.199	.004	.003	3	5
LSCC	GMFG →	+0.581	+0.200	.005	.001	3	4
GBM	THEMIS2 →	+0.685	+0.199	.002	.001	3	4
GBM	NCF1C →	+0.644	+0.263	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002923 vs PTGER4 — GBM

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