Positive regulation of humoral immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of humoral immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM9, RNMT, and RBM3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of humoral immune response activity versus TRIM9 in BLOOD_Lymphoma (Pearson r = -1.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TRIM9 →	-2.000	-1.500	<.001	.002	1	1
BLOOD_Lymphoma	RNMT →	+0.589	+1.500	.004	.002	1	1
BLOOD_Lymphoma	RBM3 →	-1.079	-1.500	.009	.002	1	1
BLOOD_Lymphoma	HAGHL →	-0.995	-1.500	.001	.002	1	1
BLOOD_Lymphoma	CLC →	-0.235	-1.500	<.001	.002	1	1
BLOOD_Lymphoma	TBC1D12 →	-0.954	-1.500	.005	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002922 vs TRIM9 — BLOOD_Lymphoma

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