Negative regulation of humoral immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of humoral immune response pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO_S838, TWF2, and SYNPO_S685, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of humoral immune response activity versus SYNPO_S838 in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SYNPO_S838 →	+0.838	+0.106	<.001	<.001	3	7
OV	TWF2 →	+0.306	+0.064	.004	.005	3	6
GBM	SYNPO_S685 →	+0.488	+0.090	<.001	<.001	3	6
GBM	CAST →	+0.355	+0.096	<.001	<.001	3	6
UCEC	COPZ2 →	+0.680	+0.106	<.001	<.001	3	6
LSCC	DFFA_S315 →	-0.494	-0.083	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002921 vs SYNPO_S838 — LSCC

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