Negative regulation of humoral immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of humoral immune response pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAS6, SEPTIN4, and GYPC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of humoral immune response activity versus GAS6 in CCRCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GAS6 →	+0.629	+0.192	<.001	<.001	3	7
GBM	SEPTIN4 →	+0.975	+0.204	.001	.002	3	6
GBM	GYPC →	+0.722	+0.159	<.001	<.001	3	6
OV	FOLR2 →	+1.011	+0.234	<.001	<.001	3	6
OV	IFFO1 →	+0.769	+0.206	<.001	<.001	3	5
OV	CXCL12 →	+1.166	+0.229	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002921 vs GAS6 — CCRCC

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