Negative regulation of humoral immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of humoral immune response pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM18, GARNL3, and FANCL, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM18 grouped by Negative regulation of humoral immune response-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RBM18 →	-0.747	-0.352	.002	.001	3	3
BREAST	GARNL3 →	-0.995	-0.292	.002	.008	3	3
LUNG_SCLC	FANCL →	-0.798	-1.090	.007	.006	3	3
LUNG_SCLC	NFIB →	-1.643	-0.751	.003	.005	3	3
LUNG_NSCLC_LUAD	ETFA →	-0.488	-0.385	.006	.008	3	3
OESOPHAGUS	KIZ →	-1.008	-0.314	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM18 by Negative regulation of humoral immune response activity — SOFT_TISSUE

Explore this box plot interactively →