Regulation of humoral immune response

Across TCGA patient cohorts, RNA activity of the Regulation of humoral immune response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TREM1, ADAM8, and SOCS3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of humoral immune response activity versus TREM1 in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TREM1 →	+0.938	+0.149	.003	.001	3	7
GBM	ADAM8 →	+0.925	+0.130	<.001	.001	3	5
HNSC	SOCS3 →	+0.611	+0.092	.007	.006	3	5
UCEC	TMEM186 →	-0.538	-0.222	.004	<.001	3	5
GBM	FAM20A →	+0.503	+0.157	.001	<.001	3	5
GBM	FCGR2A →	+1.058	+0.210	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002920 vs TREM1 — GBM

Explore this scatter interactively →