Positive regulation of myeloid leukocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEFV, CEP68, and CSF3R, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte mediated immunity activity versus MEFV in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEFV →	+0.600	+0.148	.002	.001	3	7
CCRCC	CEP68 →	-0.352	-0.264	.002	<.001	3	7
UCEC	CSF3R →	+0.936	+0.191	<.001	.003	3	7
BRCA	KLHDC2 →	-0.485	-0.266	<.001	<.001	3	7
GBM	LILRB3 →	+0.977	+0.430	<.001	.002	3	7
GBM	ADGRE2 →	+0.745	+0.324	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002888 vs MEFV — LSCC

Explore this scatter interactively →