Positive regulation of myeloid leukocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid leukocyte mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGAM, MYO1F, and PTPRC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte mediated immunity activity versus ITGAM in PDAC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ITGAM →	+0.748	+0.239	<.001	<.001	3	8
LSCC	MYO1F →	+0.422	+0.212	<.001	<.001	3	8
UCEC	PTPRC →	+0.595	+0.293	<.001	<.001	3	8
HNSC	UNC13D →	+0.451	+0.259	<.001	<.001	3	7
GBM	CAMP →	+2.121	+0.478	<.001	.001	3	7
UCEC	CCDC88B →	+0.639	+0.268	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002888 vs ITGAM — PDAC

Explore this scatter interactively →