Positive regulation of myeloid leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Positive regulation of myeloid leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ORAI3, ATRN, and PITHD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte mediated immunity activity versus ORAI3 in SOFT_TISSUE (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ORAI3 →	+1.036	+0.130	.003	<.001	3	8
KIDNEY	ATRN →	+1.095	+0.135	.002	.004	3	7
UPPER_AERODIGESTIVE_TRACT	PITHD1 →	-0.510	-0.081	.001	<.001	3	7
LUNG_NSCLC_LUSC	F2RL1 →	+2.582	+0.163	.001	.002	3	7
OESOPHAGUS	STX4 →	+1.024	+0.118	<.001	.001	3	7
KIDNEY	CTSB →	+0.931	+0.112	.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002888 vs ORAI3 — SOFT_TISSUE

Explore this scatter interactively →