Positive regulation of myeloid leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Positive regulation of myeloid leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHMT2, SCARF1, and GATC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte mediated immunity activity versus SHMT2 in BONE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SHMT2 →	+0.889	+0.279	.001	.003	3	6
BLOOD_Leukemia	SCARF1 →	-2.032	-0.183	.001	.003	3	5
BONE	GATC →	+0.872	+0.330	.001	<.001	3	5
SOFT_TISSUE	KDM4B →	+1.595	+0.221	<.001	.007	3	4
BREAST	HPSE →	-1.637	-0.143	<.001	.003	3	4
BLOOD_Leukemia	GRK5 →	+1.470	+0.174	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002888 vs SHMT2 — BONE

Explore this scatter interactively →