Negative regulation of myeloid leukocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of myeloid leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COQ3, FANCL, and CD22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myeloid leukocyte mediated immunity activity versus COQ3 in LSCC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	COQ3 →	-0.579	-0.349	<.001	.004	3	4
LSCC	FANCL →	-0.725	-0.374	<.001	.004	3	4
LUAD	CD22 →	+0.463	+0.580	<.001	<.001	3	4
LSCC	E2F6 →	-0.714	-0.436	<.001	.003	3	4
LSCC	HMGB1 →	-0.463	-0.442	<.001	.005	3	4
UCEC	CXCL2 →	+1.066	+0.561	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002887 vs COQ3 — LSCC

Explore this scatter interactively →