Negative regulation of myeloid leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Negative regulation of myeloid leukocyte mediated immunity pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1F, RNMT, and CD40LG, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPM1F grouped by Negative regulation of myeloid leukocyte mediated immunity-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPM1F →	+0.492	+2.009	<.001	<.001	3	1
BLOOD_Leukemia	RNMT →	+0.327	+1.859	.002	<.001	3	1
BLOOD_Leukemia	CD40LG →	+0.180	+1.859	.002	<.001	3	1
BLOOD_Leukemia	DNAJC17 →	+0.332	+1.859	<.001	<.001	3	1
BLOOD_Leukemia	PTPRS →	+0.242	+1.859	.001	<.001	3	1
BLOOD_Leukemia	COL1A1 →	+0.067	+1.859	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPM1F by Negative regulation of myeloid leukocyte mediated immunity activity — BLOOD_Leukemia

Explore this box plot interactively →