Regulation of myeloid leukocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Regulation of myeloid leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCRL2, IL1B, and NCF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myeloid leukocyte mediated immunity activity versus CCRL2 in UCEC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCRL2 →	+0.846	+0.347	<.001	.002	3	8
LSCC	IL1B →	+0.727	+0.221	.004	.002	3	8
UCEC	NCF1 →	+0.907	+0.408	<.001	.006	3	8
UCEC	NCF1C →	+0.723	+0.315	.003	.007	3	8
UCEC	CEACAM3 →	+0.900	+0.436	<.001	<.001	3	8
COAD	CEP68 →	-0.462	-0.262	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002886 vs CCRL2 — UCEC

Explore this scatter interactively →