Regulation of myeloid leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of myeloid leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LEKR1, CBFB, and RNFT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myeloid leukocyte mediated immunity activity versus LEKR1 in BLOOD_Leukemia (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LEKR1 →	+0.625	+0.213	.004	.004	3	5
LUNG_SCLC	CBFB →	-0.529	-0.202	.006	.007	3	4
BLOOD_Leukemia	RNFT2 →	-1.023	-0.215	.003	.003	3	4
BLOOD_Lymphoma	ASB2 →	+2.752	+0.146	.008	.004	2	4
LUNG_NSCLC_LUSC	TBX3 →	-3.770	-0.254	.008	.003	2	4
LUNG_NSCLC_LUSC	DUSP5 →	+2.010	+0.210	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002886 vs LEKR1 — BLOOD_Leukemia

Explore this scatter interactively →