Positive regulation of hypersensitivity

Across TCGA patient cohorts, RNA activity of the Positive regulation of hypersensitivity pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLA, TNFSF13B, and SCIMP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hypersensitivity activity versus SLA in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLA →	+0.789	+0.316	<.001	.002	3	7
LSCC	TNFSF13B →	+0.714	+0.395	<.001	.004	3	6
BRCA	SCIMP →	+0.529	+0.391	<.001	.001	3	6
UCEC	PARP15 →	+0.907	+0.426	<.001	<.001	3	6
UCEC	SP140 →	+0.915	+0.471	<.001	<.001	3	6
BRCA	FPR3 →	+0.611	+0.243	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002885 vs SLA — UCEC

Explore this scatter interactively →