Regulation of hypersensitivity

Across TCGA patient cohorts, RNA activity of the Regulation of hypersensitivity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB10, PTK2B_S375, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hypersensitivity activity versus PSMB10 in GBM (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSMB10 →	+0.632	+0.076	<.001	<.001	3	10
LSCC	PTK2B_S375 →	+0.329	+0.073	<.001	<.001	3	10
GBM	SASH3 →	+0.516	+0.074	<.001	.003	3	9
GBM	ELMO1 →	+0.485	+0.066	.002	.008	3	9
CCRCC	ALOX5 →	+0.573	+0.064	<.001	<.001	3	9
LSCC	HCLS1 →	+0.457	+0.089	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002883 vs PSMB10 — GBM

Explore this scatter interactively →