Regulation of hypersensitivity

Across TCGA patient cohorts, RNA activity of the Regulation of hypersensitivity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIN2, ARHGAP9, and MYO1F, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hypersensitivity activity versus BIN2 in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BIN2 →	+0.673	+0.679	<.001	<.001	3	8
GBM	ARHGAP9 →	+0.898	+0.681	<.001	.001	3	8
GBM	MYO1F →	+0.811	+0.568	<.001	<.001	3	8
OV	WAS →	+0.911	+0.430	<.001	.001	3	8
GBM	LAPTM5 →	+0.856	+0.561	<.001	.001	3	8
OV	TNFRSF1B →	+0.791	+0.371	.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002883 vs BIN2 — BRCA

Explore this scatter interactively →