Regulation of hypersensitivity

Across TCGA cell cohorts, RNA activity of the Regulation of hypersensitivity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF13, CSH1, and GAS8, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hypersensitivity activity versus PHF13 in BLOOD_Lymphoma (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PHF13 →	+0.984	+1.818	.007	<.001	3	1
BLOOD_Lymphoma	CSH1 →	+0.065	+1.873	.005	<.001	3	1
BLOOD_Lymphoma	GAS8 →	+2.365	+1.794	.004	.001	3	1
BLOOD_Lymphoma	EML4 →	+1.530	+1.818	.003	<.001	3	1
BLOOD_Lymphoma	CCDC122 →	-2.490	-1.819	<.001	.002	3	1
BLOOD_Lymphoma	SETBP1 →	+1.353	+1.818	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002883 vs PHF13 — BLOOD_Lymphoma

Explore this scatter interactively →