Positive regulation of acute inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Positive regulation of acute inflammatory response to antigenic stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMNL1_S1031, TBC1D1, and CYBA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of acute inflammatory response to antigenic stimulus activity versus FMNL1_S1031 in LSCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FMNL1_S1031 →	+0.726	+0.100	<.001	<.001	3	6
BRCA	TBC1D1 →	+0.385	+0.059	<.001	<.001	3	6
PDAC	CYBA →	+0.697	+0.053	<.001	<.001	3	6
HNSC	HLA-DMA →	+0.614	+0.063	<.001	.005	3	5
HNSC	APOL2 →	+0.643	+0.080	<.001	.001	3	5
GBM	RTN1_S352 →	+1.006	+0.083	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002866 vs FMNL1_S1031 — LSCC

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