Positive regulation of acute inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Positive regulation of acute inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCB, PZP, and CFB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of acute inflammatory response to antigenic stimulus activity versus PRKCB in GBM (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRKCB →	+1.071	+0.204	.002	.001	2	6
HNSC	PZP →	+0.841	+0.106	.001	.004	3	4
HNSC	CFB →	+0.766	+0.123	<.001	.002	3	4
UCEC	ANKRD20A5P →	+0.714	+0.133	<.001	<.001	3	4
COAD	SIGLEC10 →	+0.435	+0.116	.001	.002	3	4
COAD	IQGAP2 →	+0.533	+0.102	.007	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002866 vs PRKCB — GBM

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