Positive regulation of acute inflammatory response to antigenic stimulus

Across TCGA cell cohorts, RNA activity of the Positive regulation of acute inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT57, SEPTIN3, and SLC25A19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFT57 grouped by Positive regulation of acute inflammatory response to antigenic stimulus-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IFT57 →	-1.008	-0.928	<.001	.002	3	5
OVARY	SEPTIN3 →	+2.049	+1.465	<.001	.001	3	4
OVARY	SLC25A19 →	+0.896	+1.124	.003	.006	3	4
LUNG_SCLC	ZNF219 →	+1.159	+0.841	.004	.002	3	4
CNS	IGSF3 →	+1.545	+1.092	.004	.002	3	4
UPPER_AERODIGESTIVE_TRACT	LEPR →	-1.147	-0.994	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFT57 by Positive regulation of acute inflammatory response to antigenic stimulus activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →