Positive regulation of acute inflammatory response to antigenic stimulus

Across TCGA cell cohorts, RNA activity of the Positive regulation of acute inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP2A2, VIM, and ZNF280B, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of acute inflammatory response to antigenic stimulus activity versus AP2A2 in BLOOD_Leukemia (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AP2A2 →	-0.645	-0.120	.003	.006	3	2
BLOOD_Leukemia	VIM →	-1.698	-0.164	<.001	.002	3	1
BLOOD_Leukemia	ZNF280B →	+0.500	+0.113	.005	.004	3	1
BLOOD_Leukemia	JADE2 →	-0.836	-0.135	.002	.003	3	1
BLOOD_Leukemia	ACSM3 →	+2.927	+0.145	.001	.003	3	1
BLOOD_Leukemia	WDR54 →	-1.635	-0.197	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002866 vs AP2A2 — BLOOD_Leukemia

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